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9012395 Treatment of extracellular matrix to reduce inflammation  
Pharmaceutical compositions are provided. The compositions comprise a compound comprising the hyaluronan-containing structure A-(low molecular weight hyaluronan domain)-B. The compositions also...
8999339 Methods for treating chronic obstructive pulmonary disease  
The present invention provides methods of treating a mammal having chronic obstructive pulmonary disease (COPD), independent of both smoking status and asthma status, with a therapeutically...
8993299 Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same  
The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
8987191 Bioactive peptides and methods of using same  
Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
8986969 Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same  
The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
8980266 Serpin fusion polypeptides and methods of use thereof  
This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and...
8980826 Method of treating chronic obstructive pulmonary disease  
The present invention relates to a method of promoting bronchodilation by administration of streptolysin O to a subject in need thereof.
8974794 C(epsilon)mX peptides for inducing immune responses to human mIgE on B lymphocytes  
The invention pertains to methods of using CεmX peptides (e.g., GLAGGSAQSQRAPDRVL; SEQ ID NO:2) that can bind effectively induce immune responses to membrane-bound IgE (mIgE) expressed on the...
8940686 Cytokine  
A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine receptors. Uses of the chemokine in...
8921306 Nociceptin mimetics  
The present invention relates to nociceptin peptide mimetics that have α-helical structures and bind to and modulate the opioid receptor-like-1 (ORL-1) receptor. The peptide mimetics are...
8916517 Analogs of pituitary adenylate cyclase-activating polypeptide (PACAP) and methods for their use  
This invention relates to novel analogs of pituitary adenylate cyclase-activating polypeptide (PACAP), which are agonists for the PACAP/vasoactive intestinal peptide (VIP) receptors: PAC1, VPAC1...
8912139 Peptide compositions and methods for treating lung injury, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion  
Provided herein are peptide inhibitors of the interaction between End Binding Protein 3 (EB3) and Inositol 1,4,5-Trisphosphate Receptor Type 3 (IP3R3). Also provided are methods and materials for...
8852588 Treating allergic airway disorders using anti-IL-20 receptor antibodies  
Treatment of an allergic airway disorder (e.g., asthma or bronchial airway obstruction) using anti-IL-20R1 antibodies such as mAb51D, mAb7GW, or functional variants thereof.
8828926 Uses of natriuretic peptide constructs  
Use of constructs which bind to one or more natriuretic peptide receptors and include a plurality of amino acid residues and at least one amino acid surrogate of formula I: where R, R′, Q, Y, W,...
8828945 Inactivation of smooth muscle tissue  
Treatment and procedures for treating bodily conduits involves deactivating, killing, or otherwise treating smooth muscle tissue of the conduit.
8828394 Methods for treating IgE-mediated disorder  
This invention relates to methods of treating IgE mediated disorders such as allergy and asthma based on activating surface-bound IgD molecules on basophils. The invention also relates to methods...
8815809 Cysteine protease inhibitors  
Compounds of Formula II whereinR1a is H; and R1b is C1-C6alkyl, Carbocyclyl or Het; orR1a and R1b together define a saturated cyclic amine with 3-6 ring atoms;R2a and R2b are independently H,...
8796225 Regulation of immune responses by modulation of the function of antigen presenting cells  
The present invention relates to the use of chaperonin 10 to modulate the function of antigen presenting cells. More particularly the invention resides in the modulation of cell surface expression...
8785374 Inhibitors of mammalian tight junction opening  
The present invention provides novel peptides that inhibit and/or reduce the opening of mammalian tight junctions, i.e. peptide tight junction antagonists. The present invention also provides...
8765134 Methods for treating chronic obstructive pulmonary disease  
The present invention provides methods of treating a mammal having chronic obstructive pulmonary disease (COPD), independent of both smoking status and asthma status, with a therapeutically...
8754038 Template-fixed peptidomimetics with CCR10 antagonistic activity  
Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their...
8741835 Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment  
A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin...
8722618 IL4/IL13 binding repeat proteins and uses  
IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1...
8679503 Methods, compositions and kits relating to chitnases and chitnase-like molecules and inflammation disease  
The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic...
8637452 Water soluble membrane proteins and methods for the preparation and use thereof  
The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
8637453 Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use  
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the following formula (for convenience, collectively...
8586037 Antibodies against IL-17BR  
The invention provides the antibody D9.2 and antibody molecules based on D9.2 which bind interleukin-17 receptor B. These may be useful in therapy, e.g. the treatment of asthma, ulcerative colitis...
8580260 Method of using anti-IL-13 antibodies  
The present invention relates to human anti-IL-13 binding molecules, particularly antibodies, and to methods for using anti-IL-13 antibody molecules in diagnosis or treatment of IL-13 related...
8569229 Compositions and methods which modulate G-protein signaling for the treatment of inflammatory disorders such as asthma and allergic conjunctivitis  
Compositions and methods for the treatment of asthma and inflammatory ocular disorders are disclosed.
8541363 Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use  
The present invention pertains generally to the field of therapeutic compounds and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to...
8530407 Multi-component antioxidant compounds, pharmaceutical compositions containing same and their use for reducing or preventing oxidative stress  
An antioxidant compound is disclosed, along with pharmaceutical compositions and methods of treatment which utilize said compound. The compound is characterized by a peptide including at least...
8492329 Bioactive peptides and methods of using same  
Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
8470766 Protein kinase C therapy for the treatment of acute lung injury  
The present invention provides novel formulations of a δPKC inhibitor. The δPKC inhibitor can be, for example, a peptide. The present invention also discloses a method of preventing acute...
8440611 Analogues of neuropeptide Y having at least one synthetic amino acid substitution  
The present invention relates to novel analogues of neuropeptide Y, pharmaceutical compositions containing the same, pharmaceutical formulations containing the same, and method of treating...
8435517 Compositions and methods for treating IgE-mediated disorders  
The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such...
8372799 Reverse protein  
A protein which is composed N-terminally of one or several C-terminal parts of the amino acid sequence of the mature tumor necrosis factor and C-terminally of one or several N-terminal parts of...
8371292 Use of ciclesonide for the treatment of respiratory diseases  
The invention relates to new method of treatment of respiratory diseases, in particular the treatment of asthmatic children.
8349793 Method for treatment of inflammatory disease and disorder  
The present disclosure provides a method, composition and kit for treatment of inflammatory disease and disorder using PKC isoform modulators. Exemplary modulators include inhibitors of PKC-alpha,...
8299019 Uses of modified ELR-CXC chemokine G31P to treat cancer  
Described herein is the use of a modified human chemokine, GS-CXCL8(3-72)K11R/G31P or G31P in the treatment of a number of cancers, including but by no means limited to prostate cancer, liver...
8298547 IgE CH3 peptide vaccine  
The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of...
8287866 Methods of treating IL-TIF associated inflammatory or immune diseases using antibodies against soluble zcytor 11 cytokine receptors  
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for soluble zcytor11 receptors that may be used as novel cytokine...
8252741 Uses of modified ELR-CXC chemokine G31P  
Described herein is the use of a modified human chemokine, GS-CXCL8(3-73)K11R/G31P or G31P in the treatment of a number of diseases or disorders, including but by no means limited to pulmonary...
8221772 Pulmonary surfactant formulations and methods for promoting mucus clearance  
Methods and compositions to enhance mucus clearance and to treat pulmonary lung disorders such as cystic fibrosis are disclosed. The methods utilize compositions including synthetic pulmonary...
8138141 HMG1 antibody for treating inflammatory conditions  
There is disclosed a pharmaceutical composition and method for treating sepsis, including septic shock and ARDS (acute respiratory distress syndrome), comprising administering an effective amount...
8137701 Method of producing a dry earthworm powder  
Provided is a method of producing a dry earthworm powder without deterioration in useful pharmacological action, by removing dirt on the skin of earthworms while allowing the earthworms to excrete...
8114853 Methods of treating smooth muscle cell disorders  
The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention...
8105571 Method of treating pulmonary disease with interferons  
A method of treating a pulmonary disease such as, for instance idiophathic pulmonary fibrosis (IPF), mixed connective tissue disease and asthma, comprising administering an aerosolized interferon...
8080249 Methods to treating chronic obstructive pulmonary disease  
The present invention provides methods of treating a mammal having chronic obstructive pulmonary disease (COPD), independent of both smoking status and asthma status/with a therapeutically...
8076281 Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment  
A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin...
8071097 Apoptotic anti-IgE antibodies  
The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.

Matches 1 - 50 out of 191 1 2 3 4 >
加拿大快乐8开奖数据
北京快乐8官网开奖 快乐888 北京快乐8官网开奖 北京快乐8开奖遗漏数据 北京快乐8大小走势 快乐8官方登录 快乐8qq群 北京快乐8下载 快乐8在线下载 广东快乐8开奖历史记录 北京快乐8开奖遗漏数据 加拿大快乐8开奖时间 快乐8网址导 快乐8平台 云网快乐8福利彩票
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